Catalytic Enantioselective Synthesis of N,C,C-Trisubstituted -Amino Acid Derivatives Using 1H-Imidazol-4(5H)-ones as Key Templates

摘要

1H-Imidazol-4(5H)-ones are introduced as novel nucleophilic -amino acid equivalents in asymmetric synthesis. These compounds not only allow highly efficient construction of tetrasubstituted stereogenic centers, but unlike hitherto known templates, provide direct access to N-substituted (alkyl, allyl, aryl) -amino acid derivatives.