The (Not So) Ephemeral Trifluoromethanide Anion

摘要

The strategic value of the trifluoromcthyl group in molecular design has generated considerable interest in the development of efficient synthetic methods for its introduction. General strategies for the incorporation of this important motif encompass functional group interconversion reactions or more direct processes relying on the transfer of the complete moiety. Stoichiometric and catalytic variants of what might be considered nucleophilic (CF_3~-), clectrophilic (CF_3~+), and radical (CFV) trifluoromethylation have been described (Figure 1). In recent years, a plethora of (cata- morc commonly referred to as the Ruppert-Prakash reagent in recognition of its discoverers).