Insertion of an Alkene into an Ester: Intramolecular Oxyacylation Reaction of Alkenes through Acyl C-O Bond Activation

摘要

β-Alkoxyketones are common intermediates in organic synthesis. An unusual approach to this class of compounds could be the insertion of a C=C bond into an ester, a potentially atom economical process (Scheme 1). This alkene "oxyacy-lation" could be an alternative to the aldol reaction.Atom economy and ester manipulation, however, are rarely compatible: esters usually fragment after reactions with nucleo-philes, or decarbonylate when activated with transition metals.