High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation

摘要

there is a general agreement that obesity confers increased risk for developing cardiovascular disease and its complications, such as coronary heart disease (17). Vasomotor dysfunction of the coronary microvessels is considered to be one of the early developing alterations in obesity, contributing to the disturbed regulation of tissue perfusion and predisposing patients to myocardial ischemia (9). Studies have shown that any increase in body mass requires higher cardiac output and consequently increased coronary blood flow (14, 20, 22).