METHOD FOR THE DETECTION OF OXIDIZED FORMS OF SOLUBLE GUANYLATE CYCLASE AND A METHOD FOR SCREENING POST ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE WITH OXIDIZED HAEM IRON

摘要

The invention relates to a method for the detection of a soluble guanylatecyclase, whose haem iron is present in a trivalent oxidation state and amethod for detecting chemical substances which stimulate the activity ofsoluble guanylate cyclase when said haem iron present in soluble guanylatecyclase is at least in part trivalently oxidized. Said invention also relatesto a diagnostic agent for detecting a soluble guanylate cyclase containingtrivalent haem iron.