Salmon calcitonin reduces food intake through changes in meal sizes in male rhesus monkeys

摘要

Amylin-ergic mechanisms are believed to be involved in the control of appetite. This study examined the effects of the amylin agonist, salmon calcitonin, on food intake and meal patterns in adult male rhesus monkeys. Fifteen minutes before the onset of their 6-h daily feeding period, monkeys received intramuscular injections of various doses of salmon calcitonin (0.032, 0.056, 0.1, 0.32, and 1 |xg/kg) or saline. Salmon calcitonin dose dependently reduced total daily and hourly food intake, with significant decreases at the 0.1, 0.32, and 1 ji,g/kg doses. Daily food intake was reduced by -35%, 62%, and 96%, at these doses, respectively. An analysis of meal patterns revealed that size of the first meal was significantly reduced across the dose range of 0.056 to 1 fi-g/kg, while average meal size was reduced with the 0.32 and 1mug/kg doses. Meal number was only affected at the 1mug/kg dose. Repeated 5-day administration of the 0.1mug/kg dose resulted in a reduction in daily food intake only on injection day 2, while significant reductions in food intake were observed on all five injection days with a 0.32 jxg/kg dose.