Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury

摘要

Our understanding of the pathogenesis of disease is greatly enhanced by robust and validated experimental models. Importantly, the translation of basic biomedical knowledge to the prevention and treatment of human diseases most often requires the use of animals. However, the utility of animals to model human disease has inherent limitations, some of which cannot be overcome. The integration of new technology and the use of genetic manipulation can enhance the validity of experimental animal models. This can result in new, innovative designs that assist in advancing our knowledge of disease pathogenesis and improving our ability to test the efficacy of new drug therapies.