PPARgamma is not required for the inhibitory actions of PGJ_2 on cytokine signaling in pancreatic beta-cells

摘要

Peroxisome proliferator-activated receptor (PPAR)7 agonists, such as 15-deoxy-DELTA~(12,14)-prostaglandin J_2 (PGJ_2) and troglitazone, have been shown to elicit anti-inflammatory effects in pancreatic beta-cells that include inhibition of cytokine-stimulated inducible nitric oxide synthase (iNOS) gene expression and production of nitric oxide. In addition, these ligands impair IL-1-induced NF-KB and MAPK as well as IFN-7-stimulated signal transducer and activator of transcription (STAT)l activation in beta-cells. The purpose of this study was to determine if PPAR7 activation participates in the anti-inflammatory actions of PGJ_2 in beta-cells.