Practical Synthesis of Ethyl 1-(tert-ButoxycarbonyI)-4-(l-pyrrolidinyl)-4-piperidineacetate, an Intermediate of a Novel Antiarteriosclerotic, Utilizing Aza-Michael Addition Promoted by LiBr

摘要

The aza-Michael addition of pyrrolidine to β,β-dialkylated unsaturated ester 6 utilizing LiBr proceeded smoothly to give the inaccessible ethyl 1-(tert-butoxycarbonyl)-4-(1-pyrrolidinyl)-4-piperidineacetate (7), which is an intermediate of novel antiarteriosclerotic 1.