A 65-year-old man presented with an asymptomatic lesion on his penis. The lesion had been present for 6 years and had exhibited no change. He had been previously treated with topical antifungals and topical corticosteroids including ketoconazole cream and desonide ointment without benefit.Examination revealed discrete erythem-atous and slighdy raised plaques with dry adherent scale located on the glans and shaft of the penis. A biopsy showed squa-mous cell carcinoma in situ (Bowen's disease) of the penis. The patient preferred a non-surgical approach and therefore im-iquimod 5% cream was used. The cream was applied twice a week for 5 weeks, at which point it was discontinued because some erosions had developed. Three weeks later there was no clinical evidence of residual Bowen's disease, and no recurrence has been noticed during die next 2 years of follow-up.
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