T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.

Smith EM; Sorota S; Kim HM; McKittrick BA; Nechuta TL; Bennett C; Knutson C; Burnett DA; Kieselgof J; Tan Z; Rindgen D; Bridal T; Zhou X; Jia YP; Dong Z; Mullins D; Zhang X; Priestley T; Correll CC; Tulshian D; Czarniecki M; Greenlee WJ

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T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.

机译：T型钙通道阻滞剂：螺哌啶氮杂环丁烷和氮杂环丁烷酮的优化，设计和合成。

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A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca(V)3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the potency, selectivity and DMPK properties of leads will be described.

机译：一系列螺-氮杂环丁烷和氮杂环丁酮已被评估为T型钙通道（Ca（V）3.2）的新型阻滞剂，它是潜在治疗炎性和神经性疼痛的新治疗靶标。将描述和验证潜在性，选择性和DMPK特性的优化。

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《Bioorganic and Medicinal Chemistry Letters》 |2010年第15期|共5页
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Smith EM; Sorota S; Kim HM; McKittrick BA; Nechuta TL; Bennett C; Knutson C; Burnett DA; Kieselgof J; Tan Z; Rindgen D; Bridal T; Zhou X; Jia YP; Dong Z; Mullins D; Zhang X; Priestley T; Correll CC; Tulshian D; Czarniecki M; Greenlee WJ;
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1. T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis. [J] . Smith EM, Sorota S, Kim HM, Bioorganic and Medicinal Chemistry Letters . 2010,第15期

机译：T型钙通道阻滞剂：螺哌啶氮杂环丁烷和氮杂环丁烷酮的优化，设计和合成。
2. Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers [J] . Huy Du Nguyen, Takuya Okada, Shun Kitamura, Bioorganic and medicinal chemistry . 2018,第15期

机译：基于6-戊林宁蛋白作为T型钙通道阻滞剂的新型抗痛觉过度型药物的设计与合成
3. Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers. [J] . Kim HS, Kim Y, Doddareddy MR, Bioorganic and Medicinal Chemistry Letters . 2007,第2期

机译：设计，合成和生物学评估作为T型钙通道阻滞剂的1,3-二氧代异吲哚啉-5-羧酰胺衍生物。
4. Effects of 1-type calcium channel blockers on calcium and phosphorus metabolism and bmd of pre and post rehabilitation in chd patients [C] . Xun Liu, Yun Lv The 16th Asian Games science congress proceedings. . 2010

机译：1型钙通道阻滞剂对冠心病患者康复前后钙磷代谢和骨密度的影响
5. State-dependent block of sodium and T-type calcium channels by mibefradil. [D] . McNulty, Megan Mary. 2005

机译：米贝拉地尔依赖状态的钠和T型钙通道阻滞。
6. Anatomical localization of Cav3.1 calcium channels and electrophysiological effects of T-type calcium channel blockade in the motor thalamus of MPTP-treated monkeys [O] . Annaelle Devergnas, Erdong Chen, Yuxian Ma, -1

机译：MPTP处理的猴子的运动丘脑中Cav3.1钙通道的解剖定位和T型钙通道阻滞的电生理作用
7. Anatomical localization of Cav3.1 calcium channels and electrophysiological effects of T-type calcium channel blockade in the motor thalamus of MPTP-treated monkeys [O] . Annaelle Devergnas, Erdong Chen, Yuxian Ma, 2016

机译：CAV3.1钙通道的解剖学定位及MPTP治疗猴子电机丘脑封锁T型钙通道封锁的电生理学效应

T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.

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