Design and synthesis of dysidiolide analogs from vitamin D(3): novel class of Cdc25A inhibitors.

Shimazawa R; Suzuki T; Dodo K; Shirai R

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Design and synthesis of dysidiolide analogs from vitamin D(3): novel class of Cdc25A inhibitors.

机译：从维生素D（3）设计和合成dysidiolide类似物：新型的Cdc25A抑制剂。

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摘要

Potent dysidiolide analogs were synthesized by structural hybridization of dysidiolide and vitamin D(3). These analogs exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A (IC(50)=0.44-0.89 microM).

机译：强大的dysidiolide类似物是通过dysidiolide和维生素D（3）的结构杂交合成的。这些类似物显示出对双重特异性磷酸酶Cdc25A的强抑制活性（IC（50）= 0.44-0.89 microM）。

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《Bioorganic and Medicinal Chemistry Letters》 |2004年第12期|共4页
作者
Shimazawa R; Suzuki T; Dodo K; Shirai R;
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正文语种 eng
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dysidiolide; analogs; Vitamin D; novel; inhibitors; 维生素D;

机译：dysidiolide;analogs;Vitamin D;novel;inhibitors;维生素D;

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机译：从维生素D（3）设计和合成dysidiolide类似物：新型的Cdc25A抑制剂。
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Design and synthesis of dysidiolide analogs from vitamin D(3): novel class of Cdc25A inhibitors.

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