Efficiency of translam, a polysaccharide, as a remidy for early treatment of acute radiation sickness

摘要

Antiradiation therapeutic efficiency of translam (1 -> 3; 1 -> 6-#beta#-D-glucan) produced by enzymatic synthesis out of laminarin, polysaccharide of Laminaria cychorioides, has been studied in four animal species (mice, guinea-pigs, dogs, monkeys). A stable curative effect has been observed following its administration within first 24 h after radiation exposure at doses that cause acute radiation sickness (about LD_(90)). The preparation is nontoxic and has a broad therapeutic range which permits its practical application.