The ret/PTC1 and ret/PTC3rl rearrangements in thyroid carcinoma cells from the inhabitants of belarus after the chernobyl accident

摘要

After the accident at the Chernobyl nuclear power plant, a considerable increase in the incidence of thyroid cancer among children in Belarus was observed. in the present study, the frequency of the c-ret protooncogene rearrangements in samples of thyroid carcinomas respected and diagnosed in 1998 from individuals in Belarus was investigated. The ret/PTC1 oncogene was detected in 19% of the samples, and the ret/PTC3rl oncogene, in 14%. The number of ret/PTC1 rearrangements observed in tumor cells from the patients whose age at the time of the accident was form 1 to 10 years, was greater compared to those whose age at the time was from 10 to 20 years, irrespective of the year of surgery (1996 or 1998). The majority of the patients with retPTC3rl rearrangements lived in Gomel oblast, which was contaminated by the Chernobyl meltdown.