Association of alkaline phosphatase with acute myocardial infarction in a population with high prevalence of hypovitaminosis D

摘要

Background: Since Pakistanis have high prevalence of hypovitaminosis-D as well as acute myocardial infarction (AMI), the objective of the study was to investigate the relationship between vitamin-D deficiency and risk of AMI in a hospital-based population and to identify major risk factors for this disease. Methods: Fasting serum samples from 66 consecutive AMI patients [age 30-70. y] and 132 gender and age-matched (within 5. y) healthy controls were analyzed for concentrations of glucose, total-cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, calcium, inorganic phosphate, alkaline phosphatase (ALP), bone-ALP, parathyroid hormone (PTH), 25(OH) vitamin-D (25(OH)D) and alanine aminotransferase. Results: Mean concentrations of serum 25(OH)D, PTH, total-ALP, bone-ALP, LDL-cholesterol, HDL-cholesterol and glucose were significantly different compared to healthy controls (p. <. 0.05). Percent vitamin-D deficiency/insufficiency (levels. <. 30. ng/ml) was significantly greater in AMI patients compared to controls (93.9% vs.75.8%; p. = 0.001). Multiple conditional logistic regression analysis revealed that increased levels of 25(OH)D were associated with decreased risk of AMI [MAOR (95% CI). = 0.821 (0.718, 0.940); p. = 0.004]. Hypertension and smoking were positively associated with AMI. Conclusions: Increased vitamin-D levels were associated with decreased risk of AMI, while serum glucose, bone-ALP, hypertension and smoking were positively associated with it. Association of bone-ALP with AMI in hypovitaminosis-D is a novel finding of this study.