Evaluation of the roles of adenosine deaminase and xanthine oxidase in reperfusion injury in patients with myocardial infarction.

摘要

Dear Editor, Reactive oxygen species (ROS) are recognized as important signaling molecules in the cardiovascular system. Enhanced production of ROS, particularly O_2~(-centre dot), has been implicated in the pathogenesis of a number of cardiovascular diseases including atherosclerosis, coronary artery disease and hypertension. Increased ROS levels have been classically attributed to exposure of the ischemic tissues to molecular oxygen during reperfusion , Ischemia and reperfusion are important in human pathophysiology as they occur in various clinical conditions, for example during circulatory shock, stroke, organ transplantation and coronary artery bypass surgery .