Minimizing Skeletal Muscle Injury to Ischemia/Reperfusion with Adenosine A3 Receptor Agonists: Role of Matrix Metalloproteases.

摘要

Today's Warfighter is subject to traumatic injuries to skeletal muscle. Tourniquet use for hemorrhage control is common, as well as in surgical situations requiring the restriction of blood flow to an extremity. The reperfusion period following prolonged tourniquet use results in skeletal muscle damage, making ischemia/reperfusion (I/R) injury a concern for military personnel. In regards to acute injury, 63% of injuries sustained in combat are the result of explosive munitions that produce traumatic injury in skeletal muscle.