Biochemical and toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxinin immature male and female chickens

摘要

It has beeneported that 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)-induced body wastingin mammals is associated with decreased adipose tissue liporotein lipase (LPL) and glucose trasporting (GT) activity with differential sensitivity between genders.This study extends those findings to chickens as an avian model.A singnificant decreasein body weight gain was demonstrated in immature male and female chickens 10 days after treatmet witha single intrapertoneal (i.p.) dose of 10 and #mu#g TCDD/kg.Body weight gain decrease was associated with hepatomegly and induction of hepatic CYP1A enzymes in both genders.Theincrease iliver/body weight ratio (48%) and the decreased LPL activity (28%) were significant only in females at 10 #mu#g TCDD/kg.However,the increase inliver/body weight ratio (31%) and the decrease inLPL activity (26%) were significantly demonstrated in males at 100#mu#g TCDD/kg.Levels of GT were significantly decreased in females (46%) and in males (48%) following treatment with 10 #mu#g TCDD/kg and 100 #mu#g TCDD/kg,respectively.Therefore,in chickens,as in mammals,the TCDD-induced body wasting is accompanied with decreased LPL activity and decreased GT activity and the magnitude of these changes is gender dependent.In contrast to mammals,this stud suggests that female chickens are equally,if not more responsive to TCDD toxicity than males.