SOME ASPECTS OF REACTION OF 6-AMINOURACIL AND 6-AMINO-2-THIOURACIL WITH ct,p-UNSATURATED KETONES

摘要

A number of 5,7-diaryl-5,8-dihydropyrido[2,3-d]pyrimidines and 5,7-diarylpyrido[2,3-d]-pyrimidines were obtained by the reaction of 6-aminouracil derivatives with alpha,beta-unsaturated ketones.Basic catalysts decrease yields of the dihydro derivatives whereas acids increase it.In the reactions of ketones containing the dimethylamino group,elimination of the aryl substituent from position 5 of the pyridopyrimidine system was observed.Some aspects of oxidation of 5,8-dihydropyrido[2,3-d]pyrimidines and synthesis of pyrido[2;3-d]pyrimidines were also investigated.