Preparation of Various Ketones from the Reaction of Ketones and Alcohols Catalyzed by an Ir Complex

摘要

alpha-Alkylation of etiolates derived from ketones with alkyl halides is one of the most important and frequently used methods in organic synthesis. However, this reaction will inevitably form undesireble waste salts. In addition, the treatment of unsymmetrical ketones with a base to generate enolates results in two possible enolate ions.thus the following alkylation leads to the formation of a mixture of alpha- and alpha- alkylated products. Alternatively, if the alpha-alky lation of enolates with alkyl halides can be replaced by the direct alkylation between ketones and alcohols, this method would provide a very useful green routes to alpha-alkylatated ketones that does not produce any side products other than water.