Kupffer cell and platelet interactions in hepatic ischemia reperfusion

摘要

During liver resection, the potential for considerable intra-operative blood loss presents a major life-threatening concern and is responsible for a high perioperative morbidity and mortality [1]. In an effort to curb this potentially disastrous consequence, a technique of clamping the portal triad (known as the Pringle maneuver) was developed [2]. Initial results demonstrated that this procedure resulted in less blood loss and preservation of liver function [3]. Unfortunately, by limiting the hepatic inflow, the Pringle maneuver itself exposes the liver parenchyma to a period of ischemia-reperfusion (IR) injury, resulting in multiple complications in hepatic energy metabolism [4]. Collectively, these processes not only lead to extensive liver damage, but also may be associated with multiorgan dysfunction [5].