Intensifying insulin regimen after basal insulin optimization in adults with type 2 diabetes: a 24-week, randomized, open-label trial comparing insulin glargine plus insulin glulisine with biphasic insulin aspart (LanScape)

摘要

Aim: To test the hypothesis that a 'basal plus' regimen-adding once-daily main-meal fast-acting insulin to basal insulin once daily-would be non-inferior to biphasic insulin twice daily as assessed by glycated haemoglobin (HbA1c) concentration (predefined as <= 0.4%), but would provide superior treatment satisfaction.