Comparative Potential Therapeutic Effect of Sesame Oil and Peanut Oil against Acute Monocrotaline (Crotalaria) Poisoning in a Rat Model

摘要

Background Many Crotalaria plant species contain hepatotoxic pyrrolizidine alkaloids (such as monocrotaline) that can cause acute and chronic poisoning in cattle and other animals. Hypothesis Peanut oil, atropine sulfate, and antidiarrheal agents are used to treat acute monocrotaline poisoning. The effect of sesame on acute monocrotaline poisoning has never been investigated. Animals Fifty male Sprague-Dawley rats were used for toxicity studies. Methods Experiment 1: Group I, control. Groups IIIV were given monocrotaline (205.2 similar to mg/kg) and euthanized 6, 12, and 24 similar to hours later. Experiment 2: Group I, control. Group II monocrotaline alone (205.2 similar to mg/kg). Groups IIIVI were given monocrotaline (205.2 similar to mg/kg) and 1 similar to hour later, Groups III and IV were given sesame oil (1 and 2 similar to mL/kg) and Groups V and VI were given peanut oil (1 and 2 similar to mL/kg). Results Monocrotaline significantly decreased (P similar to