Influence of dietary supplementation with Bacillus-fermented adlay on lipid metabolism, antioxidant status and intestinal microflora in hamsters.

摘要

The effects of polished and dehulled Bacillus-fermented adlay on lipid metabolism, antioxidant status and intestinal microflora were examined in hyperlipidaemic hamsters fed a high-cholesterol diet. RESULTS: Hamsters administered Bacillus-fermented adlay experienced significantly reduced (P < 0.05) serum and hepatic total cholesterol (by 37-43% and 42-49% respectively) and triglyceride (by 22-27% and 30-35% respectively) levels compared with the high-cholesterol group. Lower low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratios in serum and increased cholesterol (by 47-52%) and triglyceride (by 40-47%) contents in faeces were also observed. Bacillus-fermented adlay lowered the levels of thiobarbituric acid-reactive substances, thus increasing total antioxidant and superoxide dismutase activities. In particular, polished Bacillus-fermented adlay had satisfactory antioxidant activity, similar to that of commercially available natto. Moreover, hamsters fed Bacillus-fermented adlay harboured greater populations of lactic acid bacteria, few coliforms and little Clostridium perfringens. CONCLUSION: This study has shown that changes in lipid metabolism, antioxidant status and intestinal microflora can be greatly modulated by Bacillus-fermented adlay, suggesting potential novel approaches to the treatment of primary cardiovascular and intestinal diseases. Copyright copyright 2011 Society of Chemical Industry.