Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow

Yu Di; Fan Changfeng; Zhang Weiyan; Wen Zhongyuan; Hu Liang; Yang Lei; Feng Yu; Yin Ke-Jie; Mo Xuming

首页> 外文期刊>Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology >Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow

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Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow

机译：尼可地尔通过PI3K / Akt1途径抑制细胞凋亡在深低温低流量小鼠模型中的神经保护作用

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Objective: Nicorandil exerts a protective effect on ischemia-reperfusion (I/R) injury in the brain and kidney through anti-apoptotic mechanisms. However, the mechanism by which nicorandil protects against I/R injury induced by deep hypothermic low flow (DHLF) remains unclear.

机译：目的：尼古拉地尔通过抗凋亡机制对脑和肾脏的缺血再灌注（I / R）损伤具有保护作用。然而，尼可地尔预防由深低温低流量（DHLF）引起的I / R损伤的机制仍不清楚。

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《Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology》 |2015年第2期|共7页
作者
Yu Di; Fan Changfeng; Zhang Weiyan; Wen Zhongyuan; Hu Liang; Yang Lei; Feng Yu; Yin Ke-Jie; Mo Xuming;
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正文语种 eng
中图分类神经病学;
关键词
Nicorandil; Deep hypothermic low flow; Neuroprotection; Apoptosis; PI3K/Akt;

机译：尼古地尔;深低温低流量;神经保护;凋亡;PI3K / Akt;

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1. Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow (vol 357, pg 119, 2015) [J] . Yu Di, Fan Changfeng, Zhang Weiyan, Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology . 2019,第期

机译：通过PI3K / AKT1途径抑制深低温低流量小鼠模型凋亡的神经保护作用（Vol 357，PG 119,2015）
2. Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow [J] . Yu Di, Fan Changfeng, Zhang Weiyan, Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology . 2015,第1a2期

机译：Nicorandil通过PI3K / AKT1途径抑制脑凋亡在深过热低流量小鼠模型中凋亡的神经保护作用
3. Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow [J] . Yu Di, Fan Changfeng, Zhang Weiyan, Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology . 2015,第1a2期

机译：尼可地尔通过PI3K / Akt1途径抑制细胞凋亡在深低温低流量小鼠模型中的神经保护作用
4. Combination of verteporfin-PDT and PI3K inhibitors enhances cell growth inhibition and apoptosis in endothelial cells [C] . Daniel Kraus, Bin Chen Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XXV . 2016

机译：Verteporfin-PDT和PI3K抑制剂的组合可增强内皮细胞的细胞生长抑制和凋亡
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Low‐molecular‐mass hyaluronan induces pulmonary inflammation by up‐regulation of Mcl‐1 to inhibit neutrophil apoptosis via PI3K/Akt1 pathway [O] . Hang Zhao, Yating Ma, Leifang Zhang 2018

机译：低分子透明质酸通过上调Mcl-1抑制肺中性粒细胞凋亡通过PI3K / Akt1途径抑制中性粒细胞凋亡
7. Corrigendum to “Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow” Journal of the Neurological Sciences Volume 357, Issues 1–2, 15 October 2015, Pages 119–125 [O] . Di Yu, Changfeng Fan, Weiyan Zhang, 2019

机译：在深过热低流量小鼠模型中，通过抑制PI3K / AKT1途径抑制细胞凋亡的“Nicorandill的神经保护作用”神经科学研究杂志357，2015年10月15日问题1-2，第119-12页第119-125页。

Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow

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