Effects of chicken treated with hwangki-beni koji sauces on body weight, serum and hepatic lipid profiles of rats fed high fat and high cholesterol diets.

摘要

The effects on serum and hepatic lipid profiles of rats fed a high fat and high cholesterol diet which included meat from chickens that had been fed a diet including hwangki-beni koji sauces (HBS) were investigated. Rats were divided into groups (5 rats per group): normal control diet (NC); high fat and high cholesterol diet (HFC); HFC plus 15% meat from chickens fed a basal diet (HFC-BS); and HFC plus 15% meat from chickens fed an HBS supplemented diet (HFC-HBS). The rats were fed the experimental diet for 5 wk. Feed intakes in the HFC-HBS group were higher than those of the HFC and HFC-BS groups, whereas body wt. gain and feed efficiency ratio of the HFC-HBS group were lower than those of the HFC and HFC-BS groups. Serum alanine aminotransferase and aspartate aminotransferase activities of the HFC-HBS group were significantly lower than those of the HFC and HFC-BS groups. Levels of serum triglyceride, total cholesterol and LDL-cholesterol in the HFC-HBS group were 34.06%, 6.28% and 31.00% lower than those of the HFC-BS group, respectively, whereas HDL-cholesterol level and atherogenic index in the HFC-HBS group were 1.72x higher and 2.52x lower, respectively, than those of the HFC-BS group. Levels of hepatic total lipids, triglyceride and total cholesterol in the HFC-HBS group were 9.53%, 5.25% and 22.20% lower than those of the HFC-BS group, respectively. Results for liver morphology showed that hepatocytes of the central vein lesion and intact hepatic cell plate are preserved well from steatosis in the HFC-HBS group, whereas the hepatocytes in the HFC and HFC-BS groups are distended by accumulation of multiple fat droplets, and sinusoids are occluded. Results suggest that diets including meat from chickens fed hwangki-beni koji sauce may have antiobesity, anticholesterol functionality and also lower the anti-atherogenic index in high fat and high cholesterol diets.