Antiobese effects of diet containing medicinal plant water extracts in high fat diet-induced obese mice.

摘要

The effects of feeding a diet containing medicinal plant water extracts (MPWE) on body wt., epididymal adipose tissue wt., adipocyte size of epididymal adipose tissue and plasma lipid levels in high fat (HF) diet-induced obese mice were investigated. To test the antiobesity effects of a diet containing MPWE, C57BL/6J mice were fed with a HF diet for 11 wk. In the last 6 wk, the HF diet was supplemented with 0 (HFD) or MPWE (5 g/kg, HFD + MPWE) or the antiobesity drug orlistat (0.5 g/kg, HFD + orlistat). An HF-free diet group was fed a normal diet for 11 wk. Feeding the HFD for 11 wk resulted in a significant increase in lipid levels, body wt., liver and epididymal adipose tissue wt., compared with the HF-free group. The diet containing MPWE significantly reduced plasma total cholesterol, LDL-cholesterol, triglyceride and glucose concn. as well as body wt., liver wt. and epididymal adipose tissue wt. Plasma triglyceride levels were significantly lower in the HFD + orlistat group after 6 wk and a similar effect was found with the HFD +MPWE group. The adipocyte size of epididymal adipose tissue in the HFD group was significantly larger than those of the HF-free group. MPWE and orlistat (positive control) significantly decreased the size of epididymal adipocytes, but orlistat was slightly more effective than MPWE. These results suggest that oral feeding of MPWE may have antiobesity effects by suppressing body wt. gain, adipose tissue formation and adipocyte size increase.