Pictet-spengler condensation of N,N-dimethylsulfamoyl-beta-phenethylamines with methylthioacetic acid ethyl ester. New synthesis of ethyl 1,2,3,4-tetrahydroisoquinoline-1-carboxylates

摘要

The reaction of N,N-dimethylsulfamoyl-beta-phenethylamines with methylthioacetic acid ethyl ester using phenyliodine(III) bis(trifluoroacetate) gives moderate to good yields of the corresponding ethyl 1,2,3,4-tetrahydroisoquinoline-1-carboxylates.