Asymmetric alkylations using SuperQuat auxiliaries-an investigation into the synthesis and stability of enolates derived from 5, 5-disubstituted oxazolidin-2-ones

摘要

Studies on the alkylation of enolates derived from a range of N-acyl-5, 5-dimethyloxazolidin-2-ones and N-acyl-5, 5-diphenyloxazolidin-2-ones reveal that high yields and high diastereoselectivities are best obtained when homochiral 4-isopropyl-5, 5-dimethyloxazolidin-2-one is employed as a chiral auxiliary.