Pronounced facial flushing and persistent erythema of rosacea effectively treated by carvedilol, a nonselective β-adrenergic blocker

摘要

To the Editor: Rosacea is a common facial disorder characterized by centrofacial erythema, flushing, telangiectasia, edema, papules, and pustules.1'2 Treatment of erythematotelangiectatic rosacea (ETR) with severe facial flushing and persistent erythema remains challenging' despite some successes with beta-adrenergic blockers,3 clonidine (a-ad-renergic agonist), naloxone. (opiate . antagonist), ondansetron (serotonin antagonist); and endoscopic thoracic sympathectomy.