The fetal mycophenolate mofetil syndrome.

摘要

Hypertelorism, epicanthal folds, arching eyebrows, thick everted lower lip, bilateral microtia with aural atresia, cleft palate, congenital tracheomalacia, brachidactyly, developmental delay.A female presented at birth with multiple congenital anomalies. Her mother had been taking 500 mg of mycophenolate mofetil (MM), twice a day and 40mg ofadalimumab every other week during the first 8 weeks of the pregnancy for lupus nephritis. No other medications were reported to have been taken. The child was born at 32 weeks' gestation by Caesarean section because of transverse position. The birth weight was 4422 g. Dysmorphic facial features noted at birth included arched eyebrows, hypertelorism, epicanthic folds, micrognathia and a thick everted lower lip. The child was also noted to have cleft palate, bilateral microtia with aural atresia (Figs 1 and 2) and brachy-dactyly.