In humans, tendinosis is a common problem that is characterized by persistent, localized, activity-related pain and swelling associated with the common calcaneal (Achilles), patellar, and supraspinatus tendons and generally caused by overuse. Diagnosis of supraspinatus tendinosis in dogs may be made on the basis of similarities in clinical, magnetic resonance imaging, and arthroscopic findings to those reported in affected humans. Histologically, affected tendons of humans are characterized by disorganized and disrupted collagen fibers (typified by loss of reflectivity under polarized light), an increase in mucoid matrix, fibro-cartilaginous metaplasia of tenocytes, and hyper-cellularity (fibroblastic-appearing cells).
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