Ruptured cerebral aneurysm in a patient with Floating-Harbor syndrome

摘要

Floating-Harbor syndrome is a rare syndrome first described by Pelletier and Feingold (1973) in a boy seen at the Boston Floating Hospital and by Leisti et al. (1975) in a patient at the Harbor General Hospital in Torrance, California. The syndrome is characterized by the presence of short stature with significantly delayed bone age, delay in expressive speech usually in the presence of normal motor development and dysmorphic facial features (Robinson et al., 1988; Patton et al., 1991). Further case reports described other associated features like feeding difficulties, fifth finger clinodactyly, finger clubbing, clavicular pseudarthrosis, coeliac disease (Chudley and Moroz, 1991), high-pitched voice, congenital heart disease (Patton et al., 1991; Lazebnik et al., 1996; Hersh et al., 1998), genitourinary anomalies (Pelletier and Feingold, 1973; Leisti et al., 1975) and spinal dysraphism (Wiltshire et al., 2005). The association of Floating-Harbour syndrome and cerebral aneurysms has never been reported before.