'No acid, no ulcer'--100 years later: a review of the history of peptic ulcer disease.

摘要

For decades, surgeons were taught and believed that peptic ulcer disease was caused by acid. The dictum "no acid, no ulcer" was engrained into every resident, and our efforts were focused on eliminating acid through operation. Our belief in the importance of acid was validated in a several ways. The cure rate of peptic ulcer disease by acid-reduction operations was substantial, impressive, and reported in the literature repeatedly. The hallmark of the Zollinger-Ellison syndrome, associated with abnormally high production of acid, was the presence of peptic ulcer disease. Antacid therapy alone for peptic ulcer disease seemed to be efficacious in the majority of patients. When newer drugs were developed, such as histamine-2 blockers like cimetidine, which effectively eliminated acid using pharmacologic means, many patients found that their ulcer disease was healed.