Biochemical and Histopathological Damages caused by Antimalarial drug, Chloroquine in Liver and Spleen of Wistar Rat

摘要

The aim of this study was to investigate the effects of chloroquine on two vital tissues in wistar rat (liver and spleen). Healthy adult male wistar rat weighing between 100 and 150 g were used for this study. The treated group was given 200 mg/kg body weight/day of chloroquine phosphate orally for 25 days. Control animals were kept on distilled water. Microscopic examination of liver and spleen tissues revealed changes in histology. The results of our study showed that prolonged exposure to the antimalarial drug chloroquine phosphate results in adverse damages on tissues.