Biochemical Parameters Response to Treadmill Exercise Training in Patients with Chronic Hepatitis C Virus Infection

摘要

Chronic hepatitis C virus infection is usually associated with abnormal liver enzymes, lipid profile and glucose hemostasis. The beneficial effects of aerobic exercise have been a matter of controversy in the field of CHC virus infection management. Objective: The aim of this study was to measure the impact of aerobic exercise training on glucose hemostasis, liver enzymes and lipid profile abnormalities among patients with CHC virus infection. Sixty non-cirrhotic CHC virus infection patients with abnormal lipid profile & non diabetic with insulin resistance. Patients were divided in to two equal groups. The first group received aerobic exercise training, three sessions per week for three months in addition to their antiviral treatment. The second group (B) received only their antiviral treatment. The mean values of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma- glutamyltransferase (GGT), insulin, homeostasis model assessment-insulin resistance-index (HOMA-IR), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c) and triglycerides (TG) were significantly decreased in group (A), where the mean value of the quantitative insulin-sensitivity check index (QUICKI) and high density lipoprotein cholesterol (HDL-c) were significantly increased, while there were no significant changes in group (B) Also; there was a significant difference between both groups at the end of the study. Treadmill walking exercise training modulates glucose hemostasis, liver enzymes and lipid profile abnormalities among patients with CHC virus infection.