A method of predicting sustained virological response in antiviral therapy of chronic hepatitis C in patients with HIV infection

摘要

FIELD: medicine.;SUBSTANCE: co-infected patients are examined to assess the dynamics of immunological markers of interferon α (IFNα), interferon γ (IFNγ) and interleukin 4 (IL-4) and their monitoring before therapy and 4 weeks after the beginning of the therapy. A stable remission is predicted if the initial cytokine count is more than 3.99 pg/ml for IFNα, from 8.32 to 13.1 pg/ml for IFNγ, if the IFNγ/IL-4 ratio is more than 6.72, whereas IFNα tends to increase as many as 100 times 4 weeks after the beginning of the therapy with IFNγ of 8.32 to 13.1 pg/ml, and the IFNγ/IL-4 ratio keeps increasing in the course of treatment by more than 6.72.;EFFECT: using the given method enables the early prediction of the clinical outcome of antiviral therapy in HIV patients.;2 ex, 4 tbl, 3 dwg