Solid Lipid Nanoparticles Preparation and Characterization

摘要

The presents study aimed to prepare and characterize Solid Lipid Nanoparticles (SLNs) from palm oil materials. Hydrogenated palm oil and lecithin incorporatedwith surfactant were mixed and formed by High Pressure Homogenization (HPH) at elevated temperature. Appropriate analytical methods are needed for the characterization of SLN. The use of several analytical techniques is a necessity such as particle size which determined using Photon Correlation Spectroscopy (PCS). The change of particle charge was studied by Zeta Potential (ZP) measurements, while the melting and recrystallization behavior characterized by Differential Scanning Calorimetry (DSC).