Modulation of Restraint Induced Gastric Oxidative Changes in Rats by Tocotrienol and Tocopherol

摘要

The present study compares the effect of tocotrienol mixture and alpha-tocopherol on gastric malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), reduced and oxidized glutathione (GSH and GSSG) content and prostaglandin E_2 level in rats exposed to restraint stress. Twenty-four male Sprague dawley rats were randomly assigned into 4 equal sized groups; twocontrol groups and two treated groups which were supplemented with either, tocotrienol (TT) or alpha-tocopherol (TF) orally at a dose of 60 mg kg~-1 body weight. After 28 days of treatment, one control group, the TT and TF groups were subjected to restraint stress, 2 h daily for 4 consecutive days. After the last exposure to stress, the stomach was excised for the evaluation of the parameters. Present findings showed that TT was better in preventing the formation of gastric lesion compared to TF while both TT and TF significantly reduces the gastric MDA content compared to stress control. We also found that both TT and TF