Hypoglycaemic and Hypolipidemic Activities of Rauwolfia serpentina in Alloxan-Induced Diabetic Rats

摘要

The prevalence of diabetes is increasing worldwide. Changes in lipid metabolism are secondary to diabetes, which may become the cause of hypertension, atherosclerosis and other cardiovascular diseases. The present study was designed to investigate the effect of methanolic root extract of Rauwolfia serpentina (a known antihypertensive herb) on glucose, total cholesterol (TC), triglycerides (TG) and alanine aminotransferase (ALT). Alloxan-induced diabetic rats were divided in to 3 groups viz., group I: diabetic control treated with 5% dimethyl sulfoxide (DMSO) in distilled water (1 mL kg~-1), group II (positive control): diabetic rats treated with known anti-diabetic drug chlorpropamide (20 mg kg~-1) and group HI (diabetic test): treated with methanolic root extract (30 mg kg~-1). Glucose was estimated from each group at 0,1,2 and 4 h after intra-peritoneal injection of each treatment by using glucometer.