OBJECTIVES: (i) To accurately define these lesions determining whether oral nicorandil-induced lesions are aphthous ulcers; (ii) To determine clinical characteristics of oral nicorandil-induced lesions. MATERIALS AND METHODS: Two slide conferences were held. A total of 60 dermatologists assigned diagnosis and clinical criteria to 11 photographs of oral nicorandil-induced lesions. Two slides were randomly selected and duplicated to be used as control. The panel of slides included independent lesions and photographs of different lesions of the same patient. Statistical analysis used chi2-test, estimation of the percentage interobserver agreement, and kappa-values. RESULTS: The diagnosis of non-aphthous ulcer (71.8%) was significantly held in comparison with the diagnosis of oral aphthous ulcer (28.2%; P < 0.001). To differentiate aphthous ulcer from non-aphthous ulcer, physicians significantly used three clinical criteria. The diagnosis of non-aphthous ulcer were significantly associated with the absenceof yellow-based ulceration (P < 0.001), with the linear shape (P = 0.006) and the absence of inflammatory halo (P = 0.003). CONCLUSION: Oral nicorandil-induced lesions are not aphthous ulcers. We propose that at this stage of our knowledge, oral nicorandil-induced ulcer is the most suitable terminology.
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机译：目的：（i）为了准确定义这些病变，确定口服尼可地尔诱发的病变是否是口腔溃疡; （ii）确定口服尼可地尔诱发的病变的临床特征。材料与方法：举行了两次幻灯片会议。共有60位皮肤科医生将诊断和临床标准分配给了11份由尼古地尔引起的口腔病变照片。随机选择两张幻灯片并重复以用作对照。幻灯片组包括独立病变和同一位患者不同病变的照片。统计分析使用chi2检验，观察者之间达成共识的百分比和kappa值的估计。结果：与口腔口腔溃疡的诊断（28.2％; P <0.001）相比，非口腔溃疡的诊断（71.8％）显着。为了区分口疮性溃疡和非口疮性溃疡，医生显着采用了三种临床标准。非口疮性溃疡的诊断与不存在基于黄色的溃疡（P <0.001），线性形状（P = 0.006）和不存在炎性晕圈（P = 0.003）密切相关。结论：口服尼可地尔诱发的病变不是口腔溃疡。我们建议，在我们所了解的这一阶段，口服尼可地尔诱发的溃疡是最合适的术语。
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