Kyphoscoliosis of an acrogigantic patient treated by pedicle subtraction osteotomy and posterior pedicle instrumented fusion

摘要

Acromegaly is a disorder of disproportionate skeletal, tissue, and organ growth, with a prevalence of 40-70 cases per million persons and an annual incidence of three to four new cases per million persons [1]. A small proportion of patients may develop gigantism if growth hormone (GH) exposure occurs before epiphyseal plate closure.Besides the local mass effect of pituitary tumor, disease pathogenesis involves GH hypersecretion by tumorous pituitary somatotrophic cells and results in multiple metabolic and structural dysfunctions. Up to 21 % of patients exhibit kyphoscoliosis [2].