A series of complications after third molar osteotomy in a pancytopenia patient and spontaneous healing after bone marrow transplantation.

摘要

Complications can result from the surgical removal of third molars, and the complication rate is expected to be higher in immunosuppressed patients. However, such cases are rare.Leflunomide is a slow-acting antirheumatic agent used in the treatment of rheumatoid arthritis and psoriatic arthritis. It inhibits dihydroorotate dehydro-genase, a key enzyme in pyrimidine metabolism that is particularly significant in the cell division of T lymphocytes, and suppresses leukocyte migration. In the intestinal wall and the liver, leflunomide is converted into its active metabolite, A771726, which is further metabolized into additional active substances. The half-life of these active leflunomide metabolites is between 1 and 4 weeks. Known side effects of le-ffunomide are itching, mucous membrane lesions, hair loss (alopecia), diarrhea, and very rarely, agranu-locytosis and fatal liver necrosis.