首页> 外文期刊>Journal of oncology pharmacy practice: official publication of the International Society of Oncology Pharmacy Practitioners >Severe and irreversible myelopathy after concurrent systemic and intrathecal nucleoside analogue treatment for refractory diffuse large B-cell lymphoma: A case report and review of the literature.
【24h】

Severe and irreversible myelopathy after concurrent systemic and intrathecal nucleoside analogue treatment for refractory diffuse large B-cell lymphoma: A case report and review of the literature.

机译:全身和鞘内核苷类似物同时治疗难治性弥漫性大B细胞淋巴瘤后的严重和不可逆性脊髓病:1例病例并文献复习。

获取原文
获取原文并翻译 | 示例
获取外文期刊封面目录资料

摘要

We report a patient with refractory diffuse large B-cell lymphoma who developed irreversible, severe spinal neurotoxicity after concurrent treatment with intrathecal and systemic cytarabine. Shortly after concomitant administration of intrathecal triple therapy (MTX, dexamethasone and cytarabine) and high-dose systemic cytarabin (R-DHAP protocol) the patient lost control of bowel and bladder function and developed an ascending, irreversible paraplegia. Infectious or neoplastic diseases of the spinal cord were ruled out. A magnetic resonance imaging scan of the spine resulted in a diagnosis of toxic myelitis. Previously observed cases of spinal neurotoxicity after cytarabine treatment are reviewed as well as current guidelines for the use of intrathecal chemotherapy in high-grade non-Hodgkin lymphoma. In summary, severe spinal neurotoxicity of intrathecal chemotherapy is a rare side-effect, however several studies suggest that the neurotoxicity of cytarabine is significantly enhanced by concurrent intrathecal and high-dose systemic administration. Simultaneous high-dose systemic and intrathecal chemotherapy with cytarabine should therefore be avoided.
机译:我们报道了一名患者难治性弥漫性大B细胞淋巴瘤患者,在鞘内和全身阿糖胞苷同时治疗后出现了不可逆的,严重的脊髓神经毒性。在同时给予鞘内三联疗法(MTX,地塞米松和阿糖胞苷)和大剂量全身性cytarabin(R-DHAP方案)后不久,患者失去了对肠和膀胱功能的控制,并出现了不可逆转的截瘫。排除了脊髓的传染性或肿瘤性疾病。脊柱的磁共振成像扫描可诊断出毒性脊髓炎。回顾了先前观察到的阿糖胞苷治疗后脊柱神经毒性的病例,以及当前在高级别非霍奇金淋巴瘤中使用鞘内化疗的指南。总之,鞘内化疗的严重脊柱神经毒性是一种罕见的副作用,但是,一些研究表明,同时进行鞘内和大剂量全身给药可大大增强阿糖胞苷的神经毒性。因此,应避免同时使用阿糖胞苷进行大剂量全身和鞘内化疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号