In 1979, Yoshiki gave a lecture in the course on pharmacology at the University of Tokyo School of Medicine. He talked mainly about the beautiful methodology that he developed with Seymour Benzer for determining the anatomical foci of behavioral abnormalities by genetic dissection of gynandromoph mosaics, i.e., how the part of the body responsible for a certain behavioral abnormality can be located on the fate map drawn on the Drosophila blastula by analyzing the phenotypes of the gynandomor-phic embryos made by the asymmetrical segregation of the ring X chromosome during the earliest stage of embryonic development. I was a medical student who had been desperately searching for the intellectual challenge that appeared to be attractive enough for my life-time dedication. His lecture for the first time in my life opened my eyes by making me aware of the existence of a huge unexplored continent, i.e., the exploration of the brain with two weapons, genetics and developmental biology. Since then, and still now, I have been possessed by this idea that was originally implanted by Yoshiki.
展开▼
