Lipase-catalyzed enantioselective deacetylation of ortho-substituted phenyl acetates with 1-butanol in organic solvents

摘要

Lipase from Candida antarctica catalyzed enantioselective deacetylation of ortho-substituted phenyl acetates with 1-butanol in organic solvents. The enantioselectivity of the lipase-catalyzed reaction depended on the nature of the substrates and the solvents employed; a significant inversion on the enantioselectivity was observed when 1,4-dioxane was used as solvent instead for cyclohexane. This work is the first example of solvent-mediated inversion of the enantioselectivity of a lipase-catalyzed deacetylation in organic solvents.