Does Haemorrhage Associated with Brain Metastases in Lung Cancer Patients Predict Early Mortality after Cranial Irradiation?

摘要

Metastatic disease in the brain is a significant source of morbidity and mortality in people with cancer. Cranial irradiation is considered, for palliation, the standard of brain metastases (BRM) care because few effective therapeutic options exist. The incidence of haemorrhagic BRM (H-BRM) in non-small cell lung cancer patients was recently reported as 1% [1]. The identification of factors that influence prognosis can be of value in clinical decision making. We hypothesised that people with lung cancer who were treated by cranial irradiation for H-BRM have a worse prognosis than those individuals with non-haemorrhagic BRM (NH-BRM).