The aim of this study was to investigate whether coenzyme Q10 (CoQ10) has an antifatigue effect in mice. ICR male mice were orally given CoQ10 in the form of Bio-Quinone (Pharma Nord, Vejle, Denmark) at doses of 0, 1.5, 15, or 45 mg/kg/day for 4 weeks. Mice were made to perform swimming exercise with loads attached to their tails, corresponding to approximately 5% of their body weights, and the total swimming time until exhaustion was measured. Furthermore, the post-exercise concentration of serum urea nitrogen (SUN), pre-/post-exercise and post-rest concentration of lactic acid (LA), and pre-exercise hepatic glycogen were determined. Mice treated with CoQ10 showed a significantly prolonged exhaustive swim time (15 mg/kg/day; P < .05), increased liver glycogen contents (15 and 45 mg/kg/day; P < .01 and P < .05, respectively), and decreased SUN levels (1.5, 15, and 45 mg/kg/day; P < .01) compared to control animals. The LA level was not significantly changed. These results suggest that CoQ10 improves swimming endurance and has an antifatigue effect.
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机译：这项研究的目的是调查辅酶Q10（CoQ10）是否对小鼠具有抗疲劳作用。以Bio-Quinone（Pharma Nord，Vejle，Denmark）的形式给ICR雄性小鼠口服CoQ10，剂量为0、1.5、15或45 mg / kg / day，持续4周。使小鼠进行游泳运动，并在其尾巴上附加负载，这相当于其体重的约5％，并测量直至疲惫为止的总游泳时间。此外，测定运动后血清尿素氮（SUN）的浓度，运动前/运动后和休息后乳酸（LA）的浓度以及运动前肝糖原的浓度。辅酶Q10处理的小鼠的疲惫游泳时间显着延长（15 mg / kg /天; P <.05），肝糖原含量增加（15和45 mg / kg / day; P <0.01和P <.05） ），与对照组相比，SUN水平降低（1.5、15和45 mg / kg /天; P <0.01）。 LA水平没有明显变化。这些结果表明辅酶Q10提高了游泳耐力并具有抗疲劳作用。
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