Design and synthesis of 2-methyl-2-(4-(2-(5-methyl-2-aryloxazol-4-yl)ethoxy)phenoxy)propionic acids: a new class of dual PPARalpha/gamma agonists.

摘要

Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARgamma- and PPARalpha-selective compounds, exhibits potent dual PPARalpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis.