...
首页> 外文期刊>Journal of Functional Foods >L-carnitine ameliorates dyslipidemic and hepatic disorders induced by a high-fat diet via regulating lipid metabolism, self-antioxidant capacity, and inflammatory response
【24h】

L-carnitine ameliorates dyslipidemic and hepatic disorders induced by a high-fat diet via regulating lipid metabolism, self-antioxidant capacity, and inflammatory response

机译:L-肉碱可通过调节脂质代谢,自身抗氧化能力和炎症反应来改善高脂饮食引起的血脂异常和肝脏疾病

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       

摘要

The cardiovascular and liver protection of carnitine (CNT) in a high-fat diet was investigated. Male C57BL/6 mice were divided randomly into four groups: 1) CON: Control, 2) HFD: high-fat diet, 3) CNTL: HFD + 500 mg CNT/kg BW, and 4) CNTH: HFD + 1500 mg CNT/kg BW. After a 25-week experimental period, CNT supplementation reduced (p <0.05) serum triacylglycerol (TAG), cholesterol crq and LDLC/HDLC ratio, and liver TAG contents. CNT supplementation downregulated (p <0.05) gene expressions of lipogenesis, but upregulated (p <0.05) gene expressions of cholesterol clearance/catabolism and energy expenditure. Serum trolox equivalent antioxidants capacity (TEAC), and liver glutathione (GSH) contents and glutathione-peroxidase (GPx) activity of HFD fed mice were also increased (p <0.05) by CNT supplementation. Besides, proinflammation related gene expressions (T1r4 and Nfkb) and proinflammatory cytokine (TNF-alpha) contents in livers of HFD fed mice were also decreased (p <0.05) by CNT supplementation. Furthermore, in comparison with the ameliorative effects of two-dosage CNT treatments on dyslipidemic and hepatic disorders induced by a high-fat diet, low dosage of CNT seems more effective than high dosage of CNT. (C) 2015 Elsevier Ltd. All rights reserved.
机译:研究了高脂饮食中肉碱(CNT)对心血管和肝脏的保护作用。将雄性C57BL / 6小鼠随机分为四组:1)CON:对照组,2)HFD:高脂饮食,3)CNTL:HFD + 500 mg CNT / kg BW,以及4)CNTH:HFD + 1500 mg CNT /千克体重。经过25周的实验期后,补充CNT可以降低(p <0.05)血清三酰甘油(TAG),胆固醇crq和LDLC / HDLC比值以及肝脏TAG含量。补充碳纳米管可降低脂肪生成的基因表达(p <0.05),但可清除胆固醇/分解代谢和能量消耗的基因表达(p <0.05)。补充CNT的HFD喂养小鼠的血清trolox当量抗氧化剂能力(TEAC),肝谷胱甘肽(GSH)含量和谷胱甘肽过氧化物酶(GPx)活性也增加(p <0.05)。此外,补充CNT的HFD喂养小鼠肝脏中与炎症相关的基因表达(T1r4和Nfkb)和炎症细胞因子(TNF-α)的含量也降低了(p <0.05)。此外,与高剂量饮食引起的血脂异常和肝脏疾病的两种剂量CNT治疗的改善作用相比,低剂量的CNT似乎比高剂量的CNT更有效。 (C)2015 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号